Adenoviral vector-based malaria vaccines
NMRC
The invention provides a method of inducing an immune response against malaria in a mammal. The method comprises intramuscularly administering to a mammal a composition comprising a pharmaceutically acceptable carrier and either or both of (a) a first adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum circumsporozoite protein (CSP) operably linked to a human CMV promoter, and/or (b) a second adenoviral vector comprising a nucleic acid sequence encoding a P. falciparum apical membrane antigen 1 (AMA-1) antigen operably linked to a human CMV promoter.
Inventors:
Bruder, Joseph T.; King, Richter C.; Richie, Thomas; Limbach, Keith; Doolan, Denise Louise
Patent Number:
Technical domain:
Materials and Coatings
FIle Date:
2013-05-09
Grant Date:
2016-02-09
Grant time:
1,006 days
Grant time percentile rank:
18
Claim count percentile rank:
7
Citations percentile rank:
1
'Cited by' percentile rank:
1
Assignee:
US NAVY
