Methods for downregulating CCR5 in T cells with anti-CD3 antibodies and anti-CD28 antibodies
NMRC
Methods for modulating HIV-1 fusion cofactor expression by manipulating an accessory molecule on the surface of T cells, such as CD28, are described. The invention encompasses methods for modulating HIV-1 fusion cofactor expression by stimulating or inhibiting one or more intracellular signals which result from ligation of a surface receptor on a T cell which binds a costimulatory molecule. In one embodiment, expression of an HIV-1 fusion cofactor, such as CCR5, is downregulated by stimulating a CD28-associated signal in the T cell.
Inventors:
June, Carl H.; Carroll, Richard G.; Riley, James L.; St. Louis, Daniel C.; Levine, Bruce L.
Patent Number:
Technical domain:
Biotechnology and Healthcare
FIle Date:
1998-02-20
Grant Date:
2011-04-19
Grant time:
4,806 days
Grant time percentile rank:
83
Claim count percentile rank:
3
Citations percentile rank:
1
'Cited by' percentile rank:
1
Assignee:
US ARMY
